WoonsocketRecruiter Since 2001
the smart solution for Woonsocket jobs

Principal Scientist

Company: Amazon Workforce Staffing
Location: Woonsocket
Posted on: September 17, 2020

Job Description:

Company: Colorado School of Mines Alumni

Location: Cambridge

Posted on: September 13, 2020

Job Description:

Colorado School of Mines Alumni Job Center Developing innovativetherapies is one of the most challenging, most essential andpersonally rewarding fields in science. This is the most excitingtime to be a part of Astellas, a company with a uniquelycollaborative and patient-focused culture.

There's something special about working at Astellas. It'sreflected in our focus on the people we serve, the way we treateach other and the results we achieve together as a company.

Astellas is announcing a Principal Scientist,Immunobiology opportunity at their Mitobridge sitein Cambridge, MA.

At Mitobridge, we are passionate about developing noveltherapeutics that improve mitochondrial function to treatdevastating human diseases. Mitochondrial dysfunction isincreasingly linked to disease pathologies and we believe that'normalizing' mitochondrial function can ameliorate or reversedisease states.

Purpose:

The role of the Principal Scientist is to build and overseepreclinical drug development programs related toimmunobiology/immunometabolism. The candidate will assumeresponsibility for the design and execution of all non-clinicalwork up to and including the IND-enabling studies and will be amajor contributor to clinical strategy leading to proof of conceptin humans.

The successful candidate will be an outstanding scientist withexpertise in immunology and experience in overseeing the design,execution and interpretation of non-clinical pharmacology andtoxicology studies. Experience preparing successful IND submissionsin a pathophysiology/biology driven approach is essential. S/hewill be expected to develop and maintain strong collaborations andrelations with external experts in the non-clinical and clinicalfields of immunology, immunometabolism, immune disorders andimmuno-oncology. The candidate will also coordinate with otherimmunology experts within the Astellas global drug development teamand seek synergies with the mitochondria primary focus.

Participate and/or lead multiple imuno-biology focused projectswithin discovery, provide scientific expertise, guidance andstrategy to successfully bringing programs to IND submission.

Propose, plan and manage and execute studies to characterize thecompany's drug candidates and their mechanism of action to moveprograms from discovery to clinical development in immune relatedindications.

Plan and implement translational research includinginvestigation of pharmacodynamics markers of target engagement,markers predictive of or correlating with clinical efficacy anddisease biology

Responsible for preparation of study reports, regulatory filingsand project presentations

Manage a portfolio of targets related to immunobiology, overseestrategic execution of discovery research and preclinicalactivities to enable robust, timely and compliant IND submissionswith clear development paths

Provide expert level guidance in designing and implementing cellbiology, in vivo pharmacology and biomarker related studies

Partner with additional immunology experts to integratemitochondria / metabolism focused programs with other immunerelated programs in the pipeline

Interface with external partners, clinical and academiccollaborators, and CROs

Provide high-level updates and advice to senior management,including evaluation of data and their potential impact on drugprograms and clinical/regulatory strategy

Lead (directly & indirectly through projects) the immuno biologyaspects of ongoing and future projects. Provide developmentopportunities and mentoring to direct reports.

Keep abreast of emerging developments regarding research anddevelopment in the fields of immune related disorders, emerging newbiology and new modalities that could facilitate identification ofnew targets or development of new therapeutics

Requirements

Qualifications:

Required

D. with 8+ years highly relevant immunobiology experience, MSwith 10+

5+ years of experience in a biopharmaceutical setting

Direct hands-on experience co-leading drug discovery projectsfrom target validation to IND-enabling studies in the immunologyfield

Demonstrated creativity and novel approaches to solvingscientific problems

Knowledge of preclinical and clinical biomarker discovery anddevelopment

Good understanding of preclinical PK/PD/efficacy relationshipsand their translation to the clinic

Strong leadership, interpersonal and communication skills withan enthusiasm for participating in a fast-paced environmentcharacterized by rigorous science and innovative thinking

Demonstrated application of expertise to drug discovery in theimmunology therapeutic area

Significant experience as a team member and/or leadingmulti-disciplinary teams focused on small molecule drugdiscovery

Experience with engaging and managing external efforts withcontract research organizations and academic collaborators

At home in a results-driven, highly accountable environmentwhere you can make a clear impact

A team player and mentor, who listens effectively and invitesresponse and discussion. A collaborator who communicates in anopen, clear, complete, timely and consistent manner

Preferred

Experience in immunobiology, mitochondrial biology, smallmolecule pharmacology.

Broad disease related experience with firsthand knowledge ineither immno-oncology and/or autoimmune diseases

Experience working within large pharma organizations and/orbiotech/start up environment

Deep understanding and experience of immunology experimentalmodels from rodents to non-human primates and human diseasesamples

#LI-JA1

Equal Opportunity Employer Minorities/Women/ProtectedVeterans/Disabled

Job Information

Job ID: 54275881

Location:

Cambridge, Massachusetts, United States

Job Function: Scientist

Job Type: Full-Time

Jobs You May Like SB

Senior Scientist, Analytical Development

Cambridge, Massachusetts, United States

T

Senior Scientist, T Cell Process Development

TCR2 Therapeutics Inc.

Cambridge, Massachusetts, United States

Sr Scientist, Molecular Design Profiling &...

Cambridge, Massachusetts, United States

P

Sr. Scientist, Structure-Based Protein Engineering

Colorado School of Mines Golden, CO 80402

Keywords: Colorado School of Mines Alumni, Cambridge , Principal Scientist, Immunobiology, Other , Cambridge, Massachusetts

Didn't find what you're looking for? Search again! Other Other Jobs

Marketing Director - CVS Media Exchange Program Lead

Description: Search by job title, category, or location Job ID: 1184166BR Location: RI - Woonsocket Street Address: 1026 Park East Dr Category: Management Marketing Job Description Serve as the CMX point (more...)

Company: CVS Health

Location: Woonsocket

Posted on: 09/14/2020

Amazon Workforce Staffing is looking for Amazon Workforce Staffing Order Pickerpacker Immediate Hir

Description: Amazon Workforce Staffing Order Pickerpacker Immediate Hire Fall River - Amazon Workforce Staffing Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, (more...)

Company: Amazon Workforce Staffing

Location: Woonsocket

Posted on: 09/14/2020

Amazon Workforce Staffing is looking for Amazon Workforce Staffing Amazon Warehouse Handler Benefit

Description: Amazon Workforce Staffing Amazon Warehouse Handler Benefits Day One - Amazon Workforce Staffing Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, (more...)

Company: Amazon Workforce Staffing

Location: Woonsocket

Posted on: 09/14/2020

Amazon Workforce Staffing Warehouse Team Member in Woonsocket

Description: Amazon Workforce Staffing Warehouse Team Member - Amazon Workforce Staffing Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, Evening, WeekendLocation (more...)

Company: Amazon Workforce Staffing

Location: Woonsocket

Posted on: 09/14/2020

Amazon Workforce Staffing is Now Re-Hiring for Amazon Workforce Staffing Warehouse Team Member

Description: Amazon Workforce Staffing Warehouse Team Member - Amazon Workforce Staffing Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, Evening, WeekendLocation (more...)

Company: Amazon Workforce Staffing

Location: Woonsocket

Posted on: 09/14/2020

Time To Re Build with Amazon Workforce Staffing Amazon Warehouse Handler Benefits Day One at Amazon

Description: Amazon Workforce Staffing Amazon Warehouse Handler Benefits Day One - Amazon Workforce Staffing Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, (more...)

Company: Amazon Workforce Staffing

Location: Woonsocket

Posted on: 09/14/2020

Urgent requirement for Amazon Workforce Staffing Amazon Warehouse Team 1516. 15 Hr Fall River in Woo

Description: Amazon Workforce Staffing Amazon Warehouse Team 1516. 15 Hr Fall River - Amazon Workforce Staffing Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, (more...)

Company: Amazon Workforce Staffing

Location: Woonsocket

Posted on: 09/14/2020

Amazon Workforce Staffing Warehouse Team Member Your Boss Is Going to Miss You Amazon Workforce Staf

Description: Amazon Workforce Staffing Warehouse Team Member - Amazon Workforce Staffing Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, Evening, WeekendLocation (more...)

Company: Amazon Workforce Staffing

Location: Woonsocket

Posted on: 09/14/2020

Amazon Workforce Staffing Order Pickerpacker Immediate Hire Fall River in Woonsocket

Description: Amazon Workforce Staffing Order Pickerpacker Immediate Hire Fall River - Amazon Workforce Staffing Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, (more...)

Company: Amazon Workforce Staffing

Location: Woonsocket

Posted on: 09/14/2020

Amazon Workforce Staffing Warehouse Team Member - Amazon Workforce Staffing

Description: Amazon Workforce Staffing Warehouse Team Member - Amazon Workforce Staffing Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, Evening, WeekendLocation (more...)

Company: Amazon Workforce Staffing

Location: Woonsocket

Posted on: 09/14/2020

Company or Job Title Location (City, State) Powered by Company reviews , salary info, and interview questions for thousands of jobs .

Keywords: Amazon Workforce Staffing, Woonsocket , Principal Scientist, Other , Woonsocket, Rhode Island

Click here to apply!

Didn't find what you're looking for? Search again!

I'm looking for
in category
within


Other Other Jobs


Full-time Warehouse Team Member - $500 sign-on bonus
Description: Full-time Warehouse Team Member - 500 sign-on bonus Hourly pay rate Earn 15.75 - 16.75/hr, plus benefits and a 500 sign-on bonus. Limited Time Opportunity Location: Taunton, MA Job opportunities vary (more...)
Company: Amazon Workforce Staffing
Location: East Providence
Posted on: 09/25/2020

Associate, Claims & Fraud Operations
Description: Associate, Claims Fraud Operations - 2002718 Description As a member of Santander---s retail banking division you---ll help serve Santander---s retail and small business customers as part of one of (more...)
Company: Santander Holdings USA Inc
Location: East Providence
Posted on: 09/25/2020

Amazon Workforce Staffing Amazon Pickerpacker Immediate Hire
Description: Amazon Workforce Staffing Amazon Pickerpacker Immediate Hire - Amazon Workforce StaffingWarehouse Team Member Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, Evening, WeekendLocation (more...)
Company: Cylcon Jobs
Location: East Providence
Posted on: 09/25/2020


Sort Center - Part-Time Up to $18/hr
Description: Full-time Warehouse Team Member - 500 sign-on bonus Hourly pay rate Earn 15.75 - 18.75/hr, plus benefits and a 500 sign-on bonus. Limited-Time Opportunity Location: Taunton, MA Job opportunities vary (more...)
Company: Amazon Workforce Staffing
Location: East Providence
Posted on: 09/25/2020

Warehouse Handler (Full-Time) - With $500 Sign-on Bonus
Description: Full-time Warehouse Team Member - 500 sign-on bonus br br Hourly pay rate: br Earn 15.75 - 18.75/hr, plus benefits and a 500 sign-on bonus. br Limited-Time Opportunity br br Location: (more...)
Company: Amazon
Location: East Providence
Posted on: 09/25/2020

Amazon Order Picker/Packer
Description: br br Warehouse Team Member Part-Time, Full-Time, Flexible Hours br br Shifts: br Overnight, Sunrise, Day, Evening, Weekend br br Location br Fall River, MA br Job opportunities vary (more...)
Company: Amazon Workforce Staffing
Location: East Providence
Posted on: 09/25/2020

Order Fulfillment Team - Regular Full Time
Description: Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, Evening, WeekendLocation Fall River, MAJob opportunities vary by location. We update postings
Company: Amazon Workforce Staffing
Location: East Providence
Posted on: 09/25/2020

Hospitality Services Associate
Description: Summary Greets, screens and provides way finding assistance while also acting as an informational resource to patients, visitors, staff and vendors. Education High school or equivalent GED . Certification, (more...)
Company: Concord Hospital
Location: Concord
Posted on: 09/25/2020

Amazon Order Picker/Packer
Description: Warehouse Team Member Seasonal, Part-Time, Full-Time, Flexible Hours Shifts: Overnight, Sunrise, Day, Evening, WeekendLocation Fall River, MAJob opportunities vary by location. We update postings
Company: Amazon Workforce Staffing
Location: East Providence
Posted on: 09/25/2020

UH-60 Utility Helicopter Repairer
Description: The UH-60 Black Hawk helicopter is the best-in-class, multi-mission performer used for combat assault, search and rescue, medevac, and firefighting missions. Your responsibility as the UH-60 Utility (more...)
Company: Army National Guard
Location: Concord
Posted on: 09/25/2020

Log In or Create An Account

Get the latest Rhode Island jobs by following @recnetRI on Twitter!

Woonsocket RSS job feeds